Proteomics

Vascular Endothelial Dysfunction Markers

We measure the following vascular endothelial and kidney function molecular markers.

Molecular marker panels for vascular endothelial function profiling:
1. NO Pathway: Asymmetric dimethyl arginine (ADMA), symmetric dimethyl arginine (SDMA), L-arginine, L-citrulline, L-ornithin
2. Homocysteine, S-adenosyl methionine, S-adenosyl homocysteine and cysteine
3. Oxidative Stress Markers: 15-f2t-isoprostane (8-epi PGF2a), glutathione
4. Uric acid
5. Amino acid profiles
6. Bioactive lipids (quantification of 19 compounds including leukotrienes (hydroxy eicosatetraenoic acids or HETEs), hydroxy eicosapentaenoic acids (HEPEs), resolvins, protectins and related hydroxy fatty acids).
All assays are LC-MS/MS assays in EDTA plasma.

In addition, serum levels of soluble intercellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1, P-selectin, E-selectin, soluble Fas and Fas ligand will be measured as markers of vascular inflammation.

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