Presentations

1. Crunk A, Christians U, Bohra R, Schöning W, Shokati T, Brunner N, Schmitz V, Lawrence R, Schniedewind B, Klawitter J,Klawitter J. Sirolimus, but not Everolimus, Enhances Tacrolimus Nephrotoxicity in the Rat. American Society of Transplantation meeting, 2009.

2. Crunk A, Christians U, Schoening W, Schmitz V, Lawrence R, Klawitter J and Klawitter J. Chronic Rejection Results in Different Changes of Urine Metabolite and Protein Patterns than immunosuppressant Toxicity in the Rat 1st AST Annual Scientific Exchange (ASE) meeting, Orlando, Florida, 2009.

3. Lanaspa MA, Andres-Hernando A, Crunk A, Rivard CJ, Li N, Christians U and Berl T. 2-bromoethanamine (BEA) induces papillary necrosis by impairing the function of TonEBP under hypertonic stress in kidney cells 48th Annual Meeting of The Society of Toxicology, Baltimore Maryland, 2009.

4. Bohra R, Schöning W, Schmitz V, Brunner N, Shokati T, Lawrence R, Schniedewind B, Klawitter J, Klawitter J, Christians U, Sirolimus and everolimus have different effects in rat kidney when combined tacrolimus. National Predoctoral Clinical Research Training Program, 2010.

5. Christians U, Hoffman K, Thomas, J, Clavijo C and Shokati T. Limitations of Sensitivity — What you look is what you will find, MSCAL, 2010.

6. Schöning W, Bohra R, Brunner N, Schmitz V, Shokati T, Lawrence R, Schniedewind B, Klawitter J, Klawitter J, Christians U. Everolimus and sirolimus have different effects in the rat kidney when combined with cyclosporine. 2010 American Transplant Congress, San Diego, CA, 2010.

7. Atkinson L, Drover DR, Clavijo C, Ting V, Harter S, Carvalho B,The Pharmacokinetic and Pharmacodynamic Effects of Prior Epidural Lidocaine Administration on Extended-Release Epidural Morphine (DepoDur) in Patients Undergoing Cesarean Delivery. SOAP, 2010.

8. Clavijo C, Thomas JJ, Christians U, Galinkin JL. An Analytical Method for the Quantification of Morphine and its Metabolites in Dried Blood Spots. WARC, 2010.

9. Thomas J, Clavijo C, Christians U, Galinkin JL. An Analytical Method to Determine Fentanyl, Despropionylfentanyl, and Norfentanyl Levels in Dried Blood Spots. WARC, 2010.

10. Clavijo C, Thomas JJ, Hoffman K ,Christians U and Galinkin JL. An LC-MS/MS Assay for the Quantification of Morphine and its Metabolites on Dried Blood Spots. American Society of Anesthesiologist Annual Meeting, 2010.

11. Clavijo C, Thomas JJ, Hammer GB,Christians U and Galinkin JL. A Sensitive LC-MS/MS Assay for Quantification of Methadone and its Metabolites in Dried Blood Spots. American Society of Anesthesiologist Annual Meeting, 2010.

12. Thomas JJ, Clavijo C, Christians U and Galinkin JL. An Analytical Method To Determine Fentanyl, Despropionylfentanyl, and Norfentanyl Levels in Dried Blood Spots. American Society of Anesthesiologist Annual Meeting, 2010.

13. Thomas JJ, Hoffman K, Clavijo C, Galinkin J, Christians U. Development of a small volume sampling technique and LC-MS orbitrap assay for pediatric pharmacokinetic studies of fentanyl and its metabolites. Mass Spectrometry: Applications to the Clinical Lab (MSACL), San Diego, CA, February 6-10, 2010

14. Clavijo C, Thomas JJ, Cohen M, Christians U, Galinkin JL. Minimal Blood volume Sampling Strategies for Therapeutic Drug Monitoring of Pain Medication in Small Children. American Society of Clinical Pharmacology and Therapeutics, 2011.

15. Bohra R, Schöning W, Schmitz V, Lawrence R, Schniedewind B, Klawitter J, Klawitter J, Christians U,Sirolimus and Differences in nephrotoxicity: combination of cyclosporine with sirolimus vs. everolimus. 2011 National Predoctoral Clinical Research Training Program, 2011.

16. Shokati T, Simons P, Davari B, Hoffman K, Byrd J, Kozac M, Zonderman M, Galinkin JL and Christians U. Toxicological Screening of 80 Drugs in Urine Using the High Resolution Exactive LC/MS Orbitrap Mass Spectrometer Coupled to Online Extraction and Turbulent Flow Chromatography. American Society of Mass Spectrometry, Colorado, Denver, 2011.

17. Crunk A, Klawitter J, Klawitter J, Rivard C, Schniedewind B and Christians U . HSP70 is a potential kidney dysfunction marker for the toxicodynamic therapeutic drug monitoring of calcineurin inhibitors. 12th International Congress of Therapeutic Drug Monitoring and Clinical Toxicology. Stuttgart, Germany, 2011

18. Hunold G, Schöning WN, Frazer-Abel A, Puhl G, Neuhaus P, Christians U. Direct cytokine measurement in urine and plasma in a rat model of chronic kidney rejection. Transplant Int 2011; 24 (Supplement 1): 209-210. Akhlaghi F, Chitnis SD, Ionita I, Christians U, Asberg A. Impact of diabetes mellitus on metabolism of immunosuppressive agents: cyclosporin, tacrolimus and prednisone. Ther Drug Monit 2011; 33: 533.

19. Crunk A, Klawitter J, Rivard C, Schniedewind B, Christians U. HSP70 is a potential kidney dysfunction marker for the toxicodynamic therapeutic drug monitoring of calcineurin inhibitors. Ther Drug Monit 2011; 33: 533-534

20. McKeown DA, Hammond GW, Christians U, Holt DW, Cooper DP. Multi-centre evaluation of the Waters MassTrak (TM) immunosuppressants XE (IUO) kit for use with LC-MS/MS for the quantification of everolimus. Ther Drug Monit 2011; 33: 541-542

21. Hunold G, Schöning WN, Frazer-Abel A, Puhl G, Neuhaus P, Christians U. Direct cytokine measurement in urine and plasma in a rat model of chronic kidney rejection. Transplant Int 2011; 24 (Suppl. 2): 209-210.

22. Schoeppler K, Lyu D, Kim I, Grazia T, Crossno J, Christians U, Zamora MR. Everolimus for calcineurin inhibitor minimization in lung transplant recipients with chronic renal insufficiency. J Heart Lung Transplant 2012; 31: S179-S180

23. Schoeppler K, Lyu D, Kim I, Grazia T, Crossno J, Christians U, Zamora MR. Everolimus with minimized tacrolimus in lung transplant recipients: 1 year efficacy and safety. Am J Transplant 2012; 12 (Suppl 3): 306-307.

24. Emoto C, Fukuda T, Cox S, Schniedewind B, Christians U, Vinks AA. In vitro metabolism of sirolimus: which cyp isoform is a major player? Drug Metab Rev 2012; 44: 52.

25. Niederlechner S, Klawitter J, Baird C, Kallweit A, Christians U, Wischmeyer P. Fibronectin stabilization and Fibronectin-Integrin signaling via MAPK are required in L-Glutamine-mediated protection against gut injury. FASEB J 2012; 26.

26. Renner B, Klawitter J, Ferreira VP, Christians U, Holers M, Thurman JM. Endothelial cells injured by the thrombotic microangiopathy-inducing drug cyclosporin release complement-activating microparticles. Immunobiology 2012, 217: 1167

27. Emoto C, Fukuda T, Cox S, Schniedewind B, Christians U, Vinks AA. Development of a physiologically-based pharmacokinetics (PBPK) model for sirolimus to explain inter-patient variability. Clin Pharmacol Ther 2013; 93: 40-41.

28. Ogasawara K, Chitnis SD, Gohh RY, Christians U, Akhlaghi F. Multidrug resistance-associated protein 2 (mrp2) affects tacrolimus disposition in a haplotype-specific manner. Clin Pharmacol Ther 2013; 93: 82.

29. Meyer EJ, Schniedewind B, Boucher R, Johnson-Davis K, Galinkin JL, Christians U. Cross-validation of everolimus LC-MS/MS and Thermo Fisher QMS Therapeutic Drug monitoring assays – The Zortracker Cross-Validation and TDM Support Program. Ther Drug Monit 2013; 35: 702.

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