Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

Congratulations! The Journal of Visualized Experiments (JOVE) published an article written by  iC42 Clinical Research and Development team lead by Dr. Uwe Christians. In the article titled ‘Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS’, describes a high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) assay to quantify the immunosuppressant tacrolimus in dried blood spots using a simple manual protein precipitation step and online column extraction.

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Our Everolimus Therapeutic Drug Monitoring Laboratory Support Program went global!

The goal of this academic program and collaboration is to provide support to set up, validate, maintain and study the performance of clinical assays for the therapeutic drug monitoring of the immunosuppressant everolimus.

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Cross-validation of Everolimus LC-MS/MS and Thermo Fisher QMS Therapeutic Drug Monitoring Assays – The Zortracker Cross-Validation and TDM Support Program

Participating Laboratories will receive Cross-Validation Kits. Cross validation results will be collated and charted in aggregate: aggregate results and each laboratory’s own results are provided bak to the laboratory monthly in a cross validation report.

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The Website just launched! is the program’s website and serves as your portal for our Everolimus TDM Laboratory Support Program. Participating laboratories can register here, can request LC‐MS/MS validation kits, supplemental patient sample kits, and monthly cross‐validation kits, and can also order customized validation samples. Results are entered via this website and iC42 will post reports on this website with your validation results. In addition, will serve as a resource for further information, exchanging experience, questions and answers related to everolimus TDM.

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